Estradiol enhances the brains responsiveness to insulin, leptin, GLP-1, and ghrelin, often through synergistic pathways such as PI3K/Akt and JAK/STAT signaling and co-transcriptional mechanisms involving factors like Cited1
Furthermore, Niacinamide is a potent anti-inflammatory
It is proposed that MA induces DA release in the MePD that activates DR1
GLP-1 receptor agonists mimic the incretin hormone GLP-1, suppressing appetite, delaying gastric emptying, and enhancing glucose-dependent insulin secretion
If fatigue becomes persistent or begins to impact your quality of life, its worth discussing with a healthcare provider to rule out other contributing factors, such as nutrient deficiencies or thyroid issues