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August 1, 2022
It was initially thought that the anti-diabetic effects of DPP-4 inhibition were predominantly due to the enhanced levels of intact GLP-1 [because the insulinotropic effect of GIP is substantially impaired in subjects with T2DM (42)], but this now seems not to be the case
The heart rate increase is a pharmacological effect, not a pathological one
Instead, it calls for coordinated involvement from a broad spectrum of healthcare professionals, including internists, endocrinologists, nutritionists, psychologists, physical activity specialists, and behavioural health experts
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