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Biomed Pharmacother 64(1):3543 Wanner A, Mendes ES (2010) Airway endothelial dysfunction in asthma and chronic obstructive pulmonary disease: a challenge for future research
Both matter
It does not require proof of efficacy in large trials the way we typically expect from drugs, but it facilitates prescribing, and that changes things a lot, because there wont be a black market anymore
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