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Severe or persistent symptoms can lead to dehydration, low food intake, weakness, or worsening kidney function in vulnerable people

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Recent investigations have shifted predominantly toward topical delivery systems, reflecting ongoing challenges with oral curcumin bioavailability despite enhancement strategies

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Metabolic pathway requiring 5-deoxyadenosylcobalamin The figure illustrates the metabolic pathway for the vitamin B 12 -dependent enzyme L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA into succinyl-CoA for entry into the citric acid cycle

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