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Nanocarriers have been shown to have a transient effect on targeted transporter plasma membrane localization as, after binding, the nanocarrier-transporter complex is internalized in the cell followed by recycling of the transporter back on the plasma membrane (82)

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The LD50 has not been established because lethal doses could not be reached in standard toxicology protocols

David DJ, Samuels BA, Rainer Q, Wang JW, Marsteller D, Mendez I, et al

Approval requires large trials establishing safety, efficacy, and proper dosing, followed by regulatory clearance and labeling