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In clinical trials, participants without diabetes on the 15 mg dose for nearly a year lost up to 22.9% of their body weight

For chronic weight management in adults with obesity, tirzepatide 15 mg delivered a mean 22.5% body weight reduction in the SURMOUNT-1 trial, compared to approximately 15% with semaglutide 2.4 mg in the STEP trials

The circadian clock maintains cardiac function by regulating mitochondrial metabolism in mice

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