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Peripherally administered GLP-1R agonists may also act directly on GLP-1R at other sites in the brain, notably circumventricular organs and some hypothalamic regions with fenestrated capillaries (101103)
Cell Signal 20:17151724 Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV (2007) Epac-mediated activation of phospholipase C plays a critical role in -adrenergic receptor-dependent enhancement of Ca 2+ mobilization in cardiac myocytes
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