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A total of 46 healthy female individuals aged 4569 years were enrolled and divided into the placebo group ( n = 23) or treatment group ( n = 23), which ingested one capsule of 500 mg of hydrolyzed fish cartilage, once a day, every night for 90 days

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Some individuals who are highly sensitive to neuroactive peptides may prefer to begin slightly lower (100150 mcg) for the first few doses to assess tolerance before moving to the full protocol

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