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FIGURE 4 3.5 FOXO4-DRI inhibits FOXO4-P53 binding and promotes P53 phosphorylation To further elucidate the specific mechanism of FOXO4-DRI in anti-aging, we induced senescence in endothelial cells under OGD conditions and treated these cells either PBS or FOXO4-DRI
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Phase-2 trials did report some benefits of ipamorelin in the condition, but the results were not deemed clinically significant within 7-10 days of therapy, leading to discontinuation of trials [9, 10]
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However, the total recovery rate was lower than 40% in iv group and less than 1% in intragastrical group, suggesting the involvement of a large number of other metabolites in vivo that have not been identified or reported in literature
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