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Preventing constipation involves three main pillars: staying highly hydrated, maintaining a consistent (but not excessive) intake of soluble fiber, and engaging in regular physical activity

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Furthermore, the study also reported that antidepressants may diminish the weight-loss effects of GLP-1 receptor agonists, potentially leading to a discrepancy between users expectations of treatment efficacy and their actual experience

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The new drugs, which were originally developed to treat diabetes, are targeting the biology that makes weight so hard to lose and keep off: They dial down hunger in the brain, slow gastric emptying, and improve post-meal insulin signaling

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Mild nausea, stomach upset, constipation, or fatigue can occur, especially early on

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