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This direct stimulation effectively promotes muscle growth and fat metabolism, particularly targeting visceral fat
Evidence supports an indirect relationship mediated by weight reduction, improved insulin sensitivity, and normalization of hormonal and inflammatory pathways
It works by upregulating growth factor expression, promoting angiogenesis, and modulating the nitric oxide system
Native IGF-1 is rapidly sequestered by IGF-binding proteins (IGFBPs) in the circulation, resulting in a half-life of approximately 1020 minutes
Complementing randomized trial evidence, extensive real-world observational data from large healthcare databases consistently demonstrate associations between GLP-1 receptor agonist utilization and decreased risks of MALOs involving cirrhosis, hepatic decompensation, HCC, and death from hepatic causes in patients with MASLD and type 2 diabetes
