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Morphological and functional metabolism studies link chronic pain and depressive disorders to dysfunctional neuroplastic changes in fronto-limbic brain regions that control emotional responses to painful injuries and stressful events

doi:10.1073/pnas.0709747104

Researchers should ensure all handling complies with relevant laboratory guidelines

Pre-existing neuropathy The case of the 75-year-old man with baseline neuropathy who developed severe allodynia on tirzepatide suggests that pre-existing nerve damage may create vulnerability

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