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Specific binding studies indicate that silent agonists stabilize certain receptor conformations favorable for interaction with endogenous neurotransmitters, potentially leading to more nuanced control of receptor activity [79, 80]
Apr 2016;4(2):161-166
As summarized by Stier, Vos, and Kenley in 2013, the pre-specified primary endpoint for statistically significant weight change across the dose range and study duration was not met, while the compound's tolerability profile remained comparable to placebo
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