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Peptide binding was assayed by EuroscreenFast (Gosselies, Belgium) or in-house with a Nicoya Open Surface Plasmon Resonance (SPR) instrument
However, the relatively small differences with exendin-asp3 suggest that additional mechanisms beyond receptor trafficking may be involved in the blunted insulin secretory response with this compound
PEG modification increased the stability of protein and peptide drugs, increased the solubility, reduced the immunogenicity, prolonged the residence time in blood, reduced the protease degradation, and reduced the frequency of drug use
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Burillo J, Marqus P, Jimnez B, et al
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