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In rare congenital sucraseisomaltase deficiency (CSID), this enzyme is severely reduced, and sucrose-containing foods can cause diarrhea, bloating, and pain.34 For such patients, prescription sucrase replacement (sacrosidase) has solid support: clinical trials show it helps children with CSID tolerate sucrose-containing meals with far fewer symptoms.35 OTC blends sometimes include invertase, but theres little direct research showing meaningful benefits in people with normal sucraseisomaltase activity

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