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This overview is intended to contextualize existing findings, without suggesting subtype-specific therapeutic applications (Table 1)

Lower thresholds likely exclude individuals without pauses in medication, whereas higher thresholds more likely relate to the actual dosage that individuals receive (i.e., those with no pauses but receiving low-to-intermediate doses are excluded with these thresholds)

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Extended storage: For longer stability extending beyond 12 months, -20C freezer storage is preferable