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Overdose depletes glutathione entirely, but even therapeutic doses can increase glutathione turnover and sometimes lower antioxidant capacity
it is banned at all times, in and out of competition, for athletes subject to anti-doping codes, and is not classified under S2 (Peptide Hormones, Growth Factors, and Related Substances), which is reserved for specifically defined peptide hormones and growth factors such as hGH and EPO
Moreover, MRP-1 gene silencing results in cellular GSSG accumulation and cell death 33
J Biol Chem (2008) 283(38):2578693
For an in-depth review on acylcarnitine functions and analysis methods, see our resource: Acylcarnitine Functions and Analysis Methods
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