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Besides the action of the GLP-1R agonist (GLP-1RA) on the brainadipocyte axis, there is also recent evidence that its direct action (independent of its CNS actions) in the white adipose tissue induces browning and enhances the lipolytic capacity and mitochondrial biogenesis [8]

Greater improvements in glycemia, estimates of insulin sensitivity and body weight were also observed with tirzepatide

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However, there are some studies that they're not in human studies these are in a dish, in vitro, or in a rodent, showing that looking at what GLP-1 does to breast cancer cells