When considering which GLP-1 receptor agonist might offer the greatest anti-inflammatory benefit , it is crucial to recognise that there is currently no definitive evidence establishing superiority of one agent over another specifically for anti-inflammatory effects

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Consistent with the incretin-mediated delivery of the PPAR// agonist, the metabolic effects of GLP-1GIPLani were blunted in DIO mice with pharmacological or genetic inhibition of GLP-1R, GIPR or PPAR, and vanished in double-incretin receptor knockout (DIR-KO) mice
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