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These microbiome changes reversed rapidly, however, when the obese mice were returned to a normal, lean diet 79

There is no identified upper limit for B12 as it's a water-soluble nutrient, meaning any excess is removed in urine

Adaptation Window Your body needs a certain timeframe to acclimatize and harness the increased B12 vitamin levels introduced

Kato K (1982)

Tissue-Level Interpretation Changes in body weight or adipose mass can result from altered food intake, hydration, lean mass, lipid synthesis, lipid mobilization, substrate oxidation, activity, thermogenesis, gastrointestinal effects, or tissue-specific adaptation