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From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models

In sum, NOS inhibition specifically during withdrawal appears to have therapeutic potential across a range of preclinical animal models, drugs of abuse, and experimental paradigms

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