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Retatrutide has not been granted a marketing authorisation by the MHRA, and it holds no approval from the FDA in the United States or the EMA in Europe either

Patients should be alert for warning signs of serious complications including: Severe, persistent abdominal pain (possibly radiating to the back or shoulder), which could indicate pancreatitis or gallbladder disease Persistent vomiting or inability to keep fluids down Yellowing of the skin or eyes (jaundice) Chest pain or persistent palpitations Additionally, cognitive and psychomotor impairment from cannabis may affect a patient's ability to adhere to medication schedules, monitor blood glucose appropriately, or recognise symptoms of hypoglycaemia or other complications

Zhang C, Xie Y, Chen H, et al

Useful tests and checks include: Blood sugar and A1C Kidney function Blood pressure Weight and body composition Any digestive symptoms Report new symptoms promptly rather than waiting for the next visit, and keep a simple journal of side effects, appetite, and energy so your provider can fine-tune your plan

Hydration status significantly impacts nausea severity