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Despite this preclinical promise, clinical translation specifically targeting JAK2/STAT3-mediated oxidative stress as the primary therapeutic strategy in acute myocardial ischemia is notably lacking, highlighting the need for more focused clinical investigation

Early use of n-acetylcysteine with nitrate therapy in patients undergoing primary percutaneous coronary intervention for ST-segment-elevation myocardial infarction reduces myocardial infarct size (the NACIAM Trial [N-acetylcysteine in Acute Myocardial Infarction])

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