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The rationale for combination use stems from the different tissue concentrations each route achieves

Gut health applications may show results sooner

But it does require physician monitoring and is contraindicated in certain conditions including active cancer

Sierra-Rivera E, Dasouki M, Summar ML, Krishnamani MR, Meredith M, Rao PN, Phillips JA, Freeman ML: Assignment of the human gene (GLCLR) that encodes the regulatory subunit of gamma-glutamylcysteine synthetase to chromosome 1p21

Thus, based on the overall findings of studies measuring glutamate, a decreased GABA/Glx ratio likely would have been observed if Glx were measured