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This creates a reinforcing cycle
The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison
Transglutaminase 2 (TG2) inhibitors Cystamine and cysteamine, as TG2 inhibitors, function as reducing agents that elevate the levels of glutathione and L-cysteine [90], thereby impacting cell metabolism
Food Chem Toxicol 112:320331
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