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Cardiovascular Effects and Tolerability of GLP-1 Receptor Agonists

In clinical trials, Ipamorelin was well tolerated, with no significant effects on prolactin or cortisol secretion compared to other GHRPs. van den Berghe et al., The Journal of Clinical Endocrinology & Metabolism Rare or Potential Concerns Injection site irritation (especially with poor reconstitution technique) Overstimulation of GH axis with excessive dosing or stacking GH-related side effects at high doses (e.g., mild carpal tunnel, joint tightness) These are more likely in unsupervised high-dose or long-term protocols , especially when paired with additional GH-enhancing compounds

This is worth raising directly with your doctor rather than ruling yourself out based on a number alone

Both retatrutide and tirzepatide are made by Eli Lilly and belong to the incretin-based class of weight loss medications

Common Mounjaro side effects typically last for a few weeks when you begin treatment and after each dose increase