However, variant interpretation is complicated by factors such as membrane targeting: for instance, a serine mutation at one of the other Na + -binding residues, N210, causes a reduction in uptake, but also shows mixed localisation, 11 which may itself contribute to disease
So I always say that, okay, I'm not saying not to drink alcohol, but I'm saying that, hey, if you're in a habit of drinking alcohol, then make sure everything surrounding that, optimize your glutathione levels by eating the right fruits, you know, reducing everything else in terms of exposure, take supplementations, whatever
Salem MA, Ismail RS, Zaki HF, Arafa HMM, El-Khatib ASN
Glutamate, at the interface between amino acid and carbohydrate metabolism
Oxford: Elsevier (2015)