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If you cannot replace lost fluids, dehydration can quickly become severe

At the 12mg dose: 58.6% of participants lost 25% or more of their body weight 39.4% of participants lost 30% or more Those thresholds are typically associated with bariatric surgery

The rationale for exploring the role of this dual agonist comes from several preclinical and early-stage clinical studies, which suggest that peptide multiagonists such as tirzepatide enhance the metabolic effects seen with GLP-1 receptor agonists [29]

Ipamorelin works through a separate ghrelin receptor pathway, telling the pituitary to release GH

If you want to understand the underlying mechanisms of these medications first, see our full guide to what is GLP-1