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[1] [3] Patients with dietary deficiency and intact absorption may require less frequent injections or may be suitable for high-dose oral supplementation instead (typically 50-150 micrograms of cyanocobalamin daily between meals)

Available research indicates it operates through enzymatic modulation rather than hormonal pathways

Malabsorption due to digestive disorders, such as Crohns disease or celiac disease, can also lead to vitamin B12 deficiency