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This flexibility did not reduce long-term effectiveness

Contact your GP or prescribing clinician if you experience cold intolerance accompanied by other symptoms that might suggest thyroid dysfunction, such as: Extreme fatigue or weakness that interferes with daily activities Unexplained weight gain or cessation of weight loss despite adherence to treatment Significant hair loss or changes in hair texture Persistent constipation unresponsive to usual measures Dry, flaky skin or changes in skin texture Muscle aches, cramps, or weakness Slowed heart rate Depression or significant mood changes Cognitive difficulties, including memory problems or difficulty concentrating These symptoms could indicate hypothyroidism , which requires investigation through thyroid function tests (TSH, free T4)

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The most commonly reported side effects in the Phase 2 trial were gastrointestinal in nature, consistent with the broader GLP-1 receptor agonist drug class

When to see a dermatologist about GLP-1 hair loss Most GLP-1 related hair loss is telogen effluvium