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Biomarker qualification: evidentiary framework
10.1161/ATVBAHA.119.313011 Arterioscler
Abstract Objectives To evaluate the effects of a very-low-calorie diet (VLCD) on insulin resistance (IR), metabolic gene expression, and fatty acid profiles in obese patients (body mass index [BMI] 30 kg/m 2 ) undergoing bariatric surgery compared to age- and sex-matched nonobese controls (BMI 25 kg/m 2 ) undergoing elective abdominal surgery
The GIPR Discovery: We found a specific variant that predicts nausea for tirzepatide usersoffering a clear biological reason why side effects vary so wildly
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