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10.1097/00041327-200020030-00006 Kim J, Park MK, Li W-Q, Qureshi AA, Cho E: Association of Vitamin A Intake With Cutaneous Squamous Cell Carcinoma Risk in the United States

First, diabetes blunts weight loss by roughly 6 to 7 percentage points versus non-diabetic obesity at the same dose, because long-standing high glucose dampens the metabolic cascade the drug works through. Second, the 10-to-15 mg step keeps adding weight loss in every band

A medicine that suits one person can be a poor fit for another

Its important to note that while NICE guidelines are influential, they are not legally binding

Xie W, Yeuh MF, Radominska-Pandya A, Saini SP, Negishi Y, Bottroff BS, Cabrera GY, Tukey RH, Evans RM (2003) Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor