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Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis

All discussion is limited to published or controlled in vitro assays and laboratory animal model research conducted under institutional oversight

When administered, it is converted to its active coenzyme forms, methylcobalamin and 5-deoxyadenosylcobalamin

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