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Sahar and Sassone-Corsi, 2012

Studies finding protective effects against cancer: A meta-analysis found that two copies of the C677T variant (AA genotype) decrease the risk of colon cancer by about 20%![ref] Another meta-analysis found that two copies of the C677T variant (AA genotype) were protective against prostate cancer .[ref] The MTHFR C677T variant decreases the relative risk of retinoblastoma and oral squamous cell cancer.[ref][ref] Two copies of the C677T variant (AA genotype) are protective against gastric cancer.[ref] However, for someone who has cancer, the MTHFR C677T variant is associated with poorer outcomes.[ref] The MTHFR A1298C variant (GG or GT) is associated with a decreased risk of hypothyroidism .[ref] The flip side: Folate can also help protect against cancerous mutations in the first place

These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]

In the studies of parasitic vaccines, different types of adjuvants can significantly enhance the effectiveness of the vaccine

The abundance of commensal Lactobacillus was increased by 2.39%, while Clostridium was decreased, which revealed the similar pattern to the culturomic approach