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If it happens occasionally, there is no need to re-dose

As shown in Figure 4, there are 11 enzymes relevant to glycolysis/gluconeogenesis upregulated in this dataset, including phosphofructokinase, aldolase, glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate kinase, enolase, and pyruvate kinase

This is particularly relevant during the early weeks of treatment when appetite suppression is most dramatic and many people dramatically reduce their food intake

This matters, because some weight thats lost during GLP-1 therapy may come from lean body mass, not just fat

The variability reflects differences in glutathione bioavailability, dosing protocols, baseline patient selenium and zinc status, and genetic factors affecting antioxidant enzyme efficiency