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The EC 50 for TGR5 ligand stimulated cAMP formation and PI hydrolysis is close to the luminal bile acids concentrations and suggests that under physiological conditions it is likely that L cells would be activated by postprandial bile acids and induce GLP-1 and PYY release

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Focus on soluble fibre (oats, cooked veggies, chia, flax, psyllium supplement) which is generally gentler on IBS