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7e and Supplementary Fig

Growth factor receptor-bound protein 2 (GRB2), an adaptor protein, binds to the receptor and recruits Son of Sevenless (SOS), a guanine nucleotide exchange factor (GEF)

TB-500's modulation of ILK activity affects downstream targets including GSK-3beta and beta-catenin, which regulate chondrocyte survival and matrix synthesis

Immune Support: It plays a crucial role in boosting the bodys immune defences