The SURMOUNT-1 trial showed an average of 22.5% weight loss at 72 weeks at 15mg, with over half of the participants reporting more than 20% loss of their body weight
Chen PH, Chang CK, Shih CM, Cheng CH, Lin CW, Lee CC, et al
Altogether, 281 patients (45 in placebo, 46 in 1.5 mg dulaglutide group, 47 in retatrutide 0.5 mg group, 23 in 4 mg escalation group, 24 in 4 mg group, 26 in 8 mg escalation group, 24 in 8 mg fast escalation group, and 46 in 12 mg escalation group) were included in the final analysis
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Some people may experience mild side effects like nausea, vomiting, or abdominal pain, but these usually go away after a few weeks