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7.2 Translational implications for endpoint interpretation and functional relevance From a translational perspective, the major challenge is not simply whether altered eating experience occurs, but how it should be interpreted across endpoint levels (76)

There have been no reported safety concerns, no significant drug-related adverse events, no deaths, and no adverse events leading to discontinuation of a study [8, 9, 10, 11, 12, 13, 14, 15]

The eIF2/PERK/ATF4 branch of the UPR also activates FGF21 under different conditions of ER stress, including change in ER redox state upon dithiothreitol treatment, or perturbation of ER calcium homeostasis with thapsigargin (156)

While BBH.1 showed no activity when -BB was supplemented, an L-carnitine biosensor fluorescence signal could be detected for BBH.2 upon addition of -BB