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2026 Update: In the SURMOUNT-5 head-to-head trial, tirzepatide produced ~47% more weight loss than semaglutide over 72 weeks

After first use, the pen can be stored for 56 days either at room temperature between 59 F to 86 F (15 C to 30 C) or in the refrigerator for 56 days

Tirzepatide, Semaglutide, and Compound Medications While brand name versions of tirzepatide and semaglutide are FDA approved (Zepbound and WeGovy respectively), generic versions are not

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"I tell my patients if they have vomiting even once, they should call my office because vomiting can be a symptom of some of the other more dangerous adverse effects," Lofton said