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Together, these findings highlight the need for further studies investigating how peripheral and central alterations interact in VPA-induced neurodevelopmental impairment (Bambini-Junior et al

It ensures mitochondria are efficient, DNA is repaired, and sirtuins are active

Importantly, the circulating soluble or secreted Klotho may have direct actions on tissues or cells that do not express Klotho

Albumin itself can also be taken up by neurons, leading to hyperexcitability and epileptogenesis (75)

Inclusion of case-control studies, which are more susceptible to bias, may explain these discrepancies among meta-analyses (128)