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PubMed Central , British Journal of Cancer , vol

It should also be avoided in patients with coexisting uncontrolled liver diseases (eg, autoimmune hepatitis), uncontrolled hypothyroidism or hyperthyroidism, symptomatic gallstone-related diseases, and ongoing alcohol consumption of 20 g or more per day for women or 30 g or more per day for men

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target is at least greater than 7% Overweight/obesity with baseline BMI ideally 25-30% +range Duration of diabetes does not affect parameters, but is usually used in patients when Metformin has proved ineffective/inadequate