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Torsional energy calculations were performed using an online torsional energy calculator 1 based on input dihedrals, which uses a combined quantum chemical ( 2 , 3 , 2 ) and empirical calculation ( 1 , 1 ) described in detail elsewhere (Haworth et al., 2

Refills are done through the same workflow, with follow-up visits handled through the patient portal

6b) but is likely conserved in others and likely makes some contribution to ligand binding 34

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The rare but serious side effects identified in trials include pancreatitis (0.3%), gallbladder events (1.4%), and acute kidney injury (0.7%)