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The role of cellular reactive oxygen species in cancer chemotherapy

These probes allow for sensitive detection of glutathionylated proteins using: Non-reducing Western blotting Biotin-specific antibodies In vivo glutathionylation proteomics Because of the biotin tag, labeled proteins can be easily enriched and visualized, making this technique particularly useful for proteome-scale studies

Likewise, ART specifically triggered ROS- and lysosomal iron-dependent cell death in pancreatic cancer cell (PDAC) lines (Eling et al., 2015)