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44 It was first used to treat type 2 diabetes (Ozempic , Novo Nordisk) as a subcutaneous injection given once weekly

The glucagon component adds three distinct mechanisms: increased hepatic energy expenditure and thermogenesis (increasing resting metabolic rate by an estimated 100-200 kcal/day), enhanced hepatic fatty acid beta-oxidation (directly reducing liver fat), and lipolysis in both hepatic and adipose tissue

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Pain assessment Joint nociception was evaluated using the von Frey test (tactile allodynia)