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If one or more potential covariables could be included in E max or ET 50 , indicating that one or several covariables would affect efficacy through influencing E max or ET 50

Another limitation of the studies was the use of different comparators ranging from placebo controls to other medications for T2DM (including insulin), which have different effects on bone tissue and were included in only one group, misleading the interpretation

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A wide spectrum of atypical nuclear changes may be seen in such lesions, but these changes generally are reactive, degenerative, or senescent phenomena rather than true anaplastic atypia characteristic of malignant transformation