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2018 [cited 2024 June 13]

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Tan et al., reported that FIIN-2, an irreversible covalent FGFR inhibitor, formed the covalent binding mode at the Cys477 residue of FGFR4 in the DGF-out conformation (96)

The fluorescence intensities of Cell Tracker Blue and CM-H 2 DCFDA were assessed via fluorescence microscopy (Eclipse 80i, Nikon Instruments Europe, Amsterdam, the Netherlands) at 20 magnification with an Ex filter of 365/28 nm, a DM of 405 nm, an Em filter of 445/50 nm, an Ex filter of 475/30 nm, a DM of 405 nm and an Em filter of 530/40 nm