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GLP-1 receptor agonists are effective for treating obesity and diabetes, but the high cost and high rates of gastrointestinal adverse effects can lead to treatment cessation and subsequent weight regain, the researchers explained

Qsymia carries pregnancy risks (topiramate causes birth defects), a more complex side effect profile including cognitive effects from topiramate, and it requires participation in a REMS risk management program

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The pH of a 1% aqueous solution of metformin hydrochloride is 6.68