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These benefits required dual GLP-1R/GLP-2R engagement, as PG-102 outperformed monospecific Fc fusion agonists or their combination and promoted coordinated receptor trafficking with delayed internalization
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Studied in: GLP-1 receptor (GLP-1R) binding and signalling research, receptor-selectivity comparisons against dual and triple agonist research compounds, peptide stability and structure-function analysis, and cell-model assay development
10.1074/jbc.M410818200 31 PiJ.BaiY.ZhangQ.WongV.FloeringL
The supplementation significantly reduced participants weight, body mass index (BMI), total cholesterol, blood sugar, insulin, and systolic blood pressure
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