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In brain, KYN is metabolized by microglia to the neurotoxic metabolite QUIN and by astrocytes to the beneficial metabolite kynurenic acid (KynA), thus, QUIN is increased and KynA is decreased in MDD patients brain

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La dcision frustante du comit amricain de la sant Timothy Caulfield, expert en droit de la sant, a affirm que la dcision du comit consultatif de la FDA tait extrmement frustrante

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